Mannings poised to renew sibling rivalry
Peyton and Eli Manning will square off for the third time in their careers when the Denver Broncos travel to the New York Giants on Sunday.
The sibling quarterbacks have three Super Bowl championships between them, with Eli winning two titles (2008 and 2012) to older brother Peyton's sole win in 2007.
However, it is Peyton who has won the previous two meetings, and he should be full of confidence after throwing for seven touchdowns in Denver's 49-27 win over Baltimore.
The San Francisco 49ers will be out for revenge when they take the trip north to meet NFC West foes, the Seattle Seahawks.
Last season's Super Bowl runners-up were beaten 42-13 in the penultimate game of the regular season at CenturyLink field in December.
San Francisco coach Jim Harbaugh will look for quarterback Colin Kaepernick to replicate his career-best 412-yard showing that guided his side to a 34-28 win over the Green Bay Packers last week as they seek payback.
The Packers will look to atone for that loss against the Washington Redskins, while two winless teams clash in the Monday game as the Cincinnati Bengals host the Pittsburgh Steelers.
Running-back Adrian Peterson will be out to inspire the Minnesota Vikings to their first win when they take on the Chicago Bears in an NFC North meeting, and defending champions the Baltimore Ravens welcome the Cleveland Browns to M&T Bank Stadium.
The New England Patriots will be out to make it consecutive wins against AFC East rivals as they do battle with the New York Jets in Foxworth on Thursday.
Bill Belichick's men were made to work hard for their 23-21 win at the Buffalo Bills, and three-time Super Bowl champion quarterback Tom Brady will be hoping for an easier encounter against Rex Ryan's side.
The Tampa Bay Buccaneers welcome the New Orleans Saints to Florida, well aware of the threat posed by Drew Brees and the Saints' dynamic passing attack, while Philadelphia Eagles head coach Chip Kelly will be out to build on their thrilling 33-27 success over the Washington Redskins against the San Diego Chargers.
Super Bowl hopefuls the Atlanta Falcons should have designs on bouncing back from an opening-day defeat to New Orleans as they host the St. Louis Rams, and the Houston Texans will hope to build momentum from their win over the Chargers as they take on the Tennessee Titans.
The Kansas City Chiefs start their home campaign against the Dallas Cowboys, while the onus will be on Andrew Luck to lead the Indianapolis Colts to another win against the Miami Dolphins.
Elsewhere the Buffalo Bills host the Carolina Panthers, the Arizona Cardinals take on the Detroit Lions and the Oakland Raiders meet the Jacksonville Jaguars.
The sibling quarterbacks have three Super Bowl championships between them, with Eli winning two titles (2008 and 2012) to older brother Peyton's sole win in 2007.
However, it is Peyton who has won the previous two meetings, and he should be full of confidence after throwing for seven touchdowns in Denver's 49-27 win over Baltimore.
The San Francisco 49ers will be out for revenge when they take the trip north to meet NFC West foes, the Seattle Seahawks.
Last season's Super Bowl runners-up were beaten 42-13 in the penultimate game of the regular season at CenturyLink field in December.
San Francisco coach Jim Harbaugh will look for quarterback Colin Kaepernick to replicate his career-best 412-yard showing that guided his side to a 34-28 win over the Green Bay Packers last week as they seek payback.
The Packers will look to atone for that loss against the Washington Redskins, while two winless teams clash in the Monday game as the Cincinnati Bengals host the Pittsburgh Steelers.
Running-back Adrian Peterson will be out to inspire the Minnesota Vikings to their first win when they take on the Chicago Bears in an NFC North meeting, and defending champions the Baltimore Ravens welcome the Cleveland Browns to M&T Bank Stadium.
The New England Patriots will be out to make it consecutive wins against AFC East rivals as they do battle with the New York Jets in Foxworth on Thursday.
Bill Belichick's men were made to work hard for their 23-21 win at the Buffalo Bills, and three-time Super Bowl champion quarterback Tom Brady will be hoping for an easier encounter against Rex Ryan's side.
The Tampa Bay Buccaneers welcome the New Orleans Saints to Florida, well aware of the threat posed by Drew Brees and the Saints' dynamic passing attack, while Philadelphia Eagles head coach Chip Kelly will be out to build on their thrilling 33-27 success over the Washington Redskins against the San Diego Chargers.
Super Bowl hopefuls the Atlanta Falcons should have designs on bouncing back from an opening-day defeat to New Orleans as they host the St. Louis Rams, and the Houston Texans will hope to build momentum from their win over the Chargers as they take on the Tennessee Titans.
The Kansas City Chiefs start their home campaign against the Dallas Cowboys, while the onus will be on Andrew Luck to lead the Indianapolis Colts to another win against the Miami Dolphins.
Elsewhere the Buffalo Bills host the Carolina Panthers, the Arizona Cardinals take on the Detroit Lions and the Oakland Raiders meet the Jacksonville Jaguars.
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